Ian Arthur York

Dept. of Microbiology & Molecular Genetics, BPS 4195,
Michigan State University,
East Lansing, MI 48824
yorki -* at *- msu.edu

Personal:
Canadian citizen / US Permanent Resident ("Green Card")
Married, two children
Born Sept. 22, 1961

Present Appointment:
Assistant Professor, Dept. of Microbiology & Molecular Genetics, Michigan State University

Research:
•Proteases and chaperones in MHC class I antigen presentation.
•Prediction of immunodominant antigens.
2006-present: Assistant Professor, Dept. of Microbiology & Molecular Genetics, Michigan State University

•Molecular mechanisms of MHC class I and MHC class II antigen presentation.
2003-2006: Research Assistant Professor, Dept. of Pathology, University of Massachusetts Medical School
2001-2003: Instructor, Dept. of Pathology, University of Massachusetts Medical School
1997-2001: Post-doctoral research fellow, lab of Kenneth Rock, Dept. of Pathology, University of Massachusetts Medical School
1994-1997: Post-doctoral research fellow, lab of Kenneth Rock, Dana-Farber Cancer Institute and Harvard University

•Evasion of the Cellular Immune Response by Herpes Simplex Virus.
1990-1994: Ph.D. research in the lab of Dr. David C. Johnson, McMaster University

•A Subunit Vaccine for Bovine Adenovirus Serotype 3.
1988-1990: M.Sc. research in the lab of Dr. Jan Thorsen, University of Guelph

Education:
1990-1994: Ph.D., Molecular Virology and Immunology Program, McMaster University, Hamilton, Ontario (Supervisor: Dr. David C. Johnson)

1988-1990: M.Sc., Dept. of Veterinary Microbiology and Immunology, University of Guelph, Guelph, Ontario (Supervisor: Dr. Jan Thorsen)

1979-1985: D.V.M., Ontario Veterinary College, University of Guelph, Guelph, Ontario

Publications:
York, I.A., N. Bhutani, S. Zendzian, A.L. Goldberg, and K.L. Rock. (2006) Tripeptidyl peptidase II (TPPII) is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation. J. Immunol. 177:1434-1443

York, I.A., M.A. Brehm, S. Zendzian, C.F. Towne, and K.L. Rock. (2006) ER-Aminopeptidase I (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in establishing immunodominance. Proc. Natl. Acad. Sci. USA 103:9202-9207

York, I.A., E.P. Grant, A.M. Dahl, and K.L. Rock. (2005) A mutant cell with a novel defect in MHC class I quality control. J. Immunol. 174:6839-6846

Rock, K.L., I.A. York, and A.L. Goldberg. (2004) Post-proteasomal antigen processing for MHC class I presentation. Nat. Immunol. 5:670-677

York, I.A., A.X.Y. Mo, K. Lemerise, W. Zeng, Y. Shen, C.R. Abraham, T. Saric, A.L. Goldberg, and K.L. Rock. (2003) The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation. Immunity 18:429-440

York, I.A., S.-C. Chang, T. Saric, J.A. Keys, J.M. Favreau, A.L. Goldberg, and K.L. Rock. (2002) The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues. Nat. Immunol. 3:1177-1184

Saric, T., S.-C. Chang, A. Hattori, I.A. York, S. Markant, K.L. Rock, M. Tsujimoto, and A.L. Goldberg. (2002) An interferon-induced aminopeptidase in the endoplasmic reticulum, ERAP1, trims precursors to MHC class I-presented peptides. Nat. Immunol. 3:1169-1176

Rock, K.L., I.A. York, T. Saric, and A.L. Goldberg. (2002) Protein degradation and the generation of MHC class I-presented peptides. Adv. Immunol. 80:1-70

York, I.A., A.L. Goldberg, X.Y. Mo, and K.L. Rock. (1999) Proteolysis and class I major histocompatibility complex antigen presentation. Immunol. Rev. 172:49-66

Russell, H.I., I.A. York, K.L. Rock, and J.J. Monaco. (1999) Class II antigen processing defects in two H2d mouse cell lines are caused by point mutations in the H2-DMa gene. Eur. J. Immunol. 29:905-911

York, I.A. (1996) Immune evasion strategies of the herpesviruses. Chem. Biol. 3:331-335

York, I.A., and K.L. Rock. (1996) Antigen processing and presentation by the class I major histocompatibility complex. Annu. Rev. Immunol.14:369-396

Tomazin, R., A.B. Hill, P. Jugovic, I. York, P. van Endert, H.L. Ploegh, D.W. Andrews, and D.C. Johnson. (1996) Stable binding of the herpes virus ICP47 protein to the peptide binding domain of TAP. EMBO J. 15:3256-3266

Hill, A., P. Jugovic, I. York, G. Russ, J. Bennink, J. Yewdell, H. Ploegh, and D. Johnson. (1995) Herpes simplex virus turns off the TAP to evade host immunity. Nature 375:411-415

York, I.A., and D.C. Johnson. (1995) Inhibition of humoral and cellular immune recognition by herpes simplex viruses. IN: Viroceptors, Virokines, and Related Immune Modulators Encoded by DNA Viruses. Ed. G. McFadden. Austin: R.G. Landes Co., pp. 89-110

Levatte, M.A., L.C. Weaver, J.R. Smiley, I.A. York, D.C. Johnson, and G.A. Dekaban. (1995) Delivery of a foreign gene to sympathetic preganglionic neurons using recombinant herpes simplex virus. Neuroscience 66:737-750

York, I.A., C. Roop, D.W. Andrews, S.R. Riddell, F.L. Graham, and D.C. Johnson. (1994) A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes. Cell 77:525-535

York, I.A., and D.C. Johnson. (1993) Direct contact with herpes simplex virus-infected cells results in inhibition of lymphokine-activated killer cells because of cell-to-cell spread of virus. J. Infect. Dis. 168:1127-1131

York, I.A., and J. Thorsen. (1992) Evaluation of a subunit vaccine for bovine adenovirus serotype 3. Am. J. Vet. Res. 53:180-183

Awards:
1994-1997: Junior Research Fellowship, National Cancer Institute of Canada 1994: Medical Research Council of Canada Fellowship (declined) 1993-1994: W. Rawls Memorial Scholarship, McMaster University 1990-1991: Centennial Scholarship, McMaster University 1980: Early In-course Scholarship, University of Guelph 1979: Early In-course Scholarship, University of Guelph

Patents:
U.S. 5,858,376 (Issued Jan 12, 1999): HSV proteins for inhibiting cell recognition by cytotoxic T lymphocytes. Johnson, David C., York, Ian A.
U.S. 5,750,398 (Issued May 12, 1998): Vector, element and method for inhibiting immune recognition. Johnson, David C., York, Ian A.

Teaching experience:
2006: Biology of Infectious Disease (Antigen presentation lecture)
2006: Core course RAPS session
2004: Advanced Immunology (Antigen Presentation session)
2003-2005: Biology of Disease (Immunology Small Group Sessions)
1998-2006: Supervised Ph.D. students in K.L. Rock's lab
1990-1994: Teaching assistant, Nursing Science and Physiology (McMaster University)
1990: Teaching assistant, Introductory Virology (University of Guelph)
1989: Teaching assistant, Introductory Veterinary Virology (University of Guelph)

Employment history:
1988-1992: Part-time veterinary practice, Toronto/Hamilton/Guelph area
1985-1987: Full-time veterinary practice, Napanee, Ontario and Willowdale, Ontario

References on request