To put this question in a slightly different but more helpful form, would it be accurate to say that a perfectly functioning human brain would have no sense of the transcendent? If we could eliminate all toxins, aberrant electrical activity, and neurotransmitter imbalances from our brains, and also ensure an adequate supply of oxygen, glucose, and other necessary substances, would we thereby achieve a permanently non-transcendent state of mind? Would we remain, from day to day and even second to second, in a permanent state of immanence, aware only of the objects presented to us by our senses, and utterly devoid of the sorts of misperceptions that sometimes lead people to believe that they have encountered God?

Richard Gunderman, “Sensing God and the Limits of Neuroscience”